Advances in Research - Part 2
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IMMUNE SYSTEM | Back to Index
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      Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol. 2011 Mar;232(1-2):196-9.
      Ashwood P, et al. Altered T cell responses in children with autism. Brain Behav Immun. 2010 Sep 15.
      Ashwood P, et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun. 2011 Jan;25(1):40-5.
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      Goines P, Van de Water J. The immune system's role in the biology of autism. Curr Opin Neurol. 2010 Apr;23(2):111-7.
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      Jyonouchi H. Food allergy and autism spectrum disorders: is there a link? Curr Allergy Asthma Rep. 2009 May;9(3):194-201.
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      Jyonouchi H, Geng L, Streck DL, Toruner GA. Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autismspectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study. J Neuroinflammation. 2012 Jan 7;9:4.
      Jyonouchi H, Geng L, Streck DL, Toruner GA. Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes. J Neuroimmunol. 2011 Jul 29.
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METABOLISM | Back to Index
      Chugani DC, Sundram BS, Behen M, Lee ML, Moore GJ. Evidence of altered energy metabolism in autistic children. Prog Neuropsychopharmacol Biol Psychiatry. 1999 May;23(4):635-41.
      Ehrhart J, Zeevalk GD. Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures. J Neurochem 2003 86(6):1487-97.
      Fernandez-Checa JC et al.      Oxidative stress: role of mitochondria and protection by glutathione. Biofactors.      1998;8(1-2):7-11.
      Filipek PA, Juranek J, et al. Relative carnitine deficiency in autism. J Autism Dev Disord 34(6): 615-23, 2004.
      Filipek PA, et al. Mitochondrial dysfunction in autistic patients with 15q inverted duplication. Ann Neurol 53(6): 801-4, 2003.
      Fillano JJ, Goldenthal MJ, et al. Mitochondrial dysfunction in patients with hypotonia, epilepsy, autism, and developmental delay: HEADD syndrome. J Child Neurol 17(6): 435-9., 2002.
      Frye RE, Rossignol DA. Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders. Pediatr Res. 2011 Feb 1.
      Gargus JJ, Imtiaz F. Mitochondrial energy-deficient endophenotype in autism. Am J Biochem Biotechnol 4(2): 198-207, 2008.
      Giulivi C, et al. Mitochondrial dysfunction in autism. JAMA. 2010 Dec 1;304(21):2389-96.
      Holtzman D. Autistic spectrum disorders and mitochondrial encephalopathies. Acta Paediatr. 2008 Jul;97(7):859-60.
      Kidd PM. Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. Altern Med Rev. 2005 Dec;10(4):268-93.
      Melnyk S, Fuchs GJ, Schulz E, Lopez M, et al. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. J Autism Dev Disord. 2012 Mar;42(3):367-77.
      Oliveira G, Ataide A, et al. Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions. Dev Med Child Neurol 49(10): 726-33, 2007.
      Oliveira G, Diogo L, et al. Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Dev Med Child Neurol 47(3): 185-9, 2005.
      Palmieri L, et al. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Mol Psychiatry. 2010 Jan;15(1):38-52.
      Palmieri L, Persico AM. Mitochondrial dysfunction in autism spectrum disorders: Cause or effect? Biochim Biophys Acta. 2010 May.
      Poling JS, et al. Developmental regression and mitochondrial dysfunction in a child with autism. J Child Neurol 21(2): 170-2, 2006.
      Pons R, Andreu AL, et al. Mitochondrial DNA abnormalities and autistic spectrum disorders. J Pediatr 144(1): 81-5, 2004.
      Rossignol DA, Bradstreet JJ. Evidence of mitochondrial dysfunction in autism and implications for treatment. A J Biochem Biotechnol 4(2): 208-217, 2008.
      Rossignol DA, Frye RE. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry. 2011 Jan 25.
      Rossignol DA, Frye RE. A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Molecular Psychiatry (2012) 17, 389–401.
      Segurado R, Conroy J, et al. Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31. Am J Psychiatry 162(11): 2182-4, 2005.
      Silverman JM, Buxbaum JD, et al. Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism. Am J Med Genet B Neuropsychiatr Genet, 2007.
      Shoffner J, et al. Fever Plus Mitochondrial Disease Could Be Risk Factors for Autistic Regression. J Child Neurol. 2009 Sep 22.
      Smith M, Spence MA, Flodman P. Nuclear and mitochondrial genome defects in autisms. Ann. N.Y. Acad. Sci. 1151:102–132, 2009.
      Trushina E, McMurray CT. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience 145(4): 1233-48, 2007.
      Tsao CY, Mendell JR. Autistic disorder in 2 children with mitochondrial disorders. J Child Neurol 2007: 22(9): 1121-3.
Weissman JR, et al. Mitochondrial disease in autism spectrum disorder patients: a cohort analysis. PLoS ONE. 2008;3(11):e3815.

NEUROLOGICAL SYMPTOMS | Back to Index
      Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4389-94.
      Anderson MP, Hooker BS, Herbert MR. Bridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and Plasticity. Am J Biochem Biotechnol 4(2): 167-176, 2008.
      Bauman ML, Kemper TL. Neuroanatomic observations of the brain in autism: a review and future directions. Int J Dev Neurosci 2005; 23:18
      Bent S, Bertoglio K, Ashwood P, Nemeth E, Hendren RL. Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial. J Autism Dev Disord. 2011 Aug 5..
      Corbett BA, Mendoza S, et al. Cortisol circadian rhythms and response to stress in children with autism. Psychoneuroendocrinology 2006: 31(1): 59-68.
      Corbett BA, Schupp CW, Levine S, Mendoza S. Comparing cortisol, stress, and sensory sensitivity in children with autism. Autism Res. 2009 Feb;2(1):39-49.
      De Miranda J, et al. Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5. FASEB J. 2009 Apr;23(4):1064.
      Deutsch SI, Urbano MR, Neumann SA, Burket JA, Katz E. Cholinergic abnormalities in autism: is there a rationale for selective nicotinic agonist interventions? Clin Neuropharmacol. 2010 May;33(3):114-20.
      Erickson CA, Posey DJ, Stigler KA, Mullett J, Katschke AR, McDougle CJ. A retrospective study of memantine in children and adolescents with pervasive developmental disorders. Psychopharmacology (Berl). 2006 Oct 3.
      Friedman SD, Shaw DW, Artru AA, Richards TL, Gardner J, Dawson G, Posse S, Dager SR. Regional brain chemical alterations in young children with autism spectrum disorder. Neurology. 2003 Jan 14;60(1):100-7.
      Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA. Cerebral folate receptor autoantibodies in autism spectrum disorder. Mol Psychiatry. 2012 Jan 10.
      Frye RE, Huffman LC, Elliott GR. Tetrahydrobiopterin as a novel therapeutic intervention for autism. Neurotherapeutics. 2010 Jul;7(3):241-9.
      Frye RE, Sreenivasula S, Adams JB. Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line sur-vey. BMC Pediatrics 2011, 11:37.
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NUTRITIONAL DEFICIENCIES, SUPPLEMENTS & DIET | Back to Index
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OXIDATIVE STRESS | Back to Index
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